Mild to moderate attacks such as for example bronchitis and higher respiratory system infections were somewhat higher in the group taking the drug – – 38 % compared with 32 % in the placebo group. ‘It’s a fine line between trying to modulate the immune system and suppressing it to an degree that you are at an increased risk for infections,’ said Genovese. The bigger threat of less serious attacks is something to bear in mind with abatacept. ‘If you modulate the disease fighting capability you are at a potential risk,’ he said, ‘but you just have thoroughly weigh the risks and the huge benefits.’.. Abatacept, marketed as Orencia appears to offer pain relief and increased mobility to rheumatoid arthritis patients A new drug appears to offer treatment and increased mobility to arthritis rheumatoid patients who’ve exhausted their other medical treatment options.This added benefit cannot be produced from the dossier, however, because the drug manufacturer didn’t submit any appropriate data. Studies just compared single-dose administration of the medications The maker presented two randomized controlled trials with crossover design for the direct assessment with octocog alfa. Their main outcome criterion was pharmacokinetics such as for example excretion and ingestion of the drug. In these two studies, the individuals received a single dosage of simoctocog alfa or octocog alfa and – after a wash-out phase – a second single dose of the respective other drug. Patients with haemophilia need longterm treatment and prevention of bleeding. European Medicines Company guidelines consequently recommend a minimum duration of six months for studies that try to test advantages and drawbacks of haemophilia drugs used for prophylaxis.