The researchers completed a parallel four group , randomised managed trial among 2,591 non-pregnant smokers who called the English NHS smoking helpline between February 2009 and February 2010. Each smoker was randomly assigned to one of four groups: Standard support – NHS Stop Smoking Services advice and access to helpline Standard support with free nicotine alternative therapy Proactive support -consisting of extra and regular scheduled phone and message support from helpline staff. Proactive support with free Related StoriesNew analysis shows nicotine raises codeine-induced analgesiaHenry Ford Medical center pulmonologist advocates for increasing the cigarette smoking age to 21Community health guidelines targeting smokers could possibly have opposite effect, study finds The proactive groups were contacted by counsellors before their agreed stop date, on the day itself, and then at 3,7,14 and 21 times after quitting.Probably the most valuable component of this workout was the realization that better studies are needed to specifically determine which current treatments work the very best under different clinical circumstances. We also came up with some helpful ideas on how best to design future research, said Dr. Lichtman. Creating this Guideline A lot more than 4,000 journal articles from around the world were analyzed during the period of a season and every article was graded on a five-point scale with respect to the strength and quality of the data.