Steven McNulty.

Chew, M.B., B.S., M.P.H., William J. French, M.D., Franz Leisch, M.D., Keyur H. Parikh, M.D., Simona Skerjanec, Pharm.D., and Deepak L. Bhatt, M.D., M.P.H.: Platelet Inhibition with Cangrelor in Patients Undergoing PCI Percutaneous coronary intervention might be complicated by adverse cardiac events including death, myocardial infarction, a dependence on urgent revascularization, and acute, subacute, or late stent thrombosis, whether or not bare-metal or drug-eluting stents are used. 1-3 As a result, antithrombotic therapy is an essential adjunct to PCI.4 Clinical practice suggestions recommend treatment with antiplatelet agents, including clopidogrel, after and during PCI, although the optimal timing, loading dose, and duration of therapy haven’t been established by randomized clinical trials definitively.5,6 Current guidelines suggest an oral loading dosage of 300 to 600 mg of clopidogrel accompanied by 75 mg daily.11,12 Ticagrelor was superior to clopidogrel in patients with acute coronary syndromes, and prasugrel was superior to clopidogrel in patients with acute coronary syndromes who have been undergoing PCI.13,14 Cangrelor, a nonthienopyridine adenosine triphosphate analogue, is definitely in a course of intravenous blockers of the ADP receptor P2Y12 that might have a role in the treatment of patients who require quick, predictable, and profound but reversible platelet inhibition.15 A direct-acting, selective, and specific P2Y12 inhibitor, cangrelor is metabolized through dephosphorylation pathways and includes a plasma half-life of 3 to 6 minutes.Related StoriesNew RNA test of blood platelets may be used to detect location of cancerMeat-rich diet may increase kidney cancers riskInner ear damage brain warnings from nerve cellsThe results, in the February problem of the journal Anesthesia and Analgesia published, shed additional light on Aetna, Humana and additional large health insurers’ recent decisions to discontinue payment for the usage of the sedative propofol during most routine colonoscopies, because it generally requires an anesthesiologist to be present to monitor for adverse reactions during the process.