The potential of this approach in a previous Phase I open-label. It was not yet in a randomized double-blind study to be confirmed.Andrew Feigin of The Feinstein Institute for Medical Research, New York, and his team set up a double-blind randomized study to determine what would be the effect if they delivered the GAD camp AAV2 into the subthalamic nucleus of 22 volunteers, compared with 23 people in the control group . For a period of six months after surgery, the researchers UPDRS was used to assess motor function of all 45 patients.
‘has changed the use of somatic cell gene transfer on gene expression in well-characterized brain neurochemical systems, a novel alternative to conventional pharmacological. Or surgical treatment This study justifies the continued development of AAV2 – GAD for treatment of Parkinson’s disease and shows the promise of gene therapy for other neurological disorders ‘.
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